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In BV2 cells, the inflammatory factor IL-6 was upregulated after FAC exposure, in turn, DMT1 was upregulated and FPN1 was downregulated following 24 hours of IL-6 stimulation, which resulted in iron overload (44)

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It has shown better diagnostic and grading capabilities for liver steatosis when compared with controlled attenuation parameter modality using transient elastography (122)

Variants in SLC19A1 have been associated with impaired MTX transport and resistance, while SLCO1B1 low-activity haplotypes have been linked to delayed MTX clearance and increased toxicity risk (Wang et al